We have a new paper out in Neurobiology of Learning and Memory, on “Autism Spectrum Disorders: Translating human deficits into mouse behavior”, taking a closer look at at how the typical behaviors seen in human autism spectrum disorders can be modelled in mice. And an added bonus – we got the cover!
Amyloid precursor protein (APP) was known to be an mRNA targeted by FMRP for translation regulation, but in this new study, lead by Dr Emanuela Pasciuto, we identified a molecular mechanism that leads to increased levels and maturation of the soluble APPα in the FXS mouse model. A lack of FMRP in early development leads to excessive production of APP and its regulating secretase, ADAM10, affecting neuronal development and behavior. This indicates an important role for the non-amyloidogenic pathway of APP processing in pathological processes.The paper was published in Neuron (see here for Pubmed link). Also see here for coverage on the VIB website and here for a great write up in the AlzForum.
A new paper from the lab sheds light on the role of the Fragile X mental retardation-protein 2 (FXR2P) in translational control. The study was lead by staff scientist Dr Esperanza Fernandez and is published in the Journal of Neuroscience. We showed that FMRP binding to PSD95 requires cooperation with FXR2P, and this coordinated regulation is involved in fine tuning PSD95 activity during synaptic plasticity. See here for the Pubmed link.