Pubmed author search: Bagni C


Achsel T, Bagni C. (2016) Cooperativity in RNA-protein interactions: the complex is more than the sum of its partners. Curr Opin Neurobiol. 2016 Jun 25;39:146-151. Pubmed

Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri AR. (2016) Altered neuronal network and rescue in a human MECP2 duplication model. Molecular Psychiatry. Feb;21(2):178-88. Pubmed


Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H. (2015) Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. EMBO Mol Med. 2015 Nov 26;7(12):1565-79. Pubmed

Pasciuto E, Borrie SC, Kanellopoulos AK, Santos AR, Cappuyns E, D’Andrea L, Pacini L, Bagni C. (2015) Autism Spectrum Disorders: Translating human deficits into mouse behaviour. Neurobiology of Learning and Memory. Published online July 26, 2015. Pubmed

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D’Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D’Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C. (2015) Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome. Neuron, 87:382-398. Pubmed

Fernández E, Li KW, Rajan N, De Rubeis S, Fiers M, Smit AB, Achsel T, Bagni C. (2015) FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression. Journal of Neuroscience, 35(25):9402-8. Pubmed

Di Marino D, D’Annessa I, Tancredi H, Bagni C, Gallicchio E. (2015) A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors. Protein Science, 24(9):1370-82. Pubmed

Braat S, D’Hulst C, Heulens I, De Rubeis S, Mientjes E, Nelson DL, Willemsen R, Bagni C, Van Dam D, De Deyn PP, Kooy RF. (2015) The GABAA Receptor is an FMRP Target with Therapeutic Potential in Fragile X Syndrome. Cell Cycle. Published online March 19, 2015. Pubmed

Di Marino D, Chillemi G, De Rubeis S, Tramontano A, Achsel T, Bagni C. (2015) MD and Docking Studies Reveal that the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion. J Chem Theory Comput. 11(7):3401-10. Pubmed

Rossi S, Serrano A, Gerbino V, Giorgi A, Di Francesco L, Nencini M, Bozzo F, Schininà ME, Bagni C, Cestra G, Carrì MT, Achsel T, Cozzolino M. (2015) Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS. Journal of Cell Science, 128(9):1787-99. Pubmed


Panja D, Kenney JW, D’Andrea L, Zalfa F, Vedeler A, Wibrand K, Fukunaga R, Bagni C, Proud CG, Bramham CR. (2014) Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Reports, 9(4):1430-45. Pubmed

La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C. (2014) FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nature Neuroscience, 17(12):1693-700. Pubmed

Pasciuto E, Bagni C. (2014) SnapShot: FMRP interacting proteins. Cell, 159(1):218. Pubmed

Santos AR, Kanellopoulos AK, Bagni C. (2014) Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us. Learning and Memory, 21:543-555. Pubmed

Pasciuto E, Bagni C. (2014) SnapShot: FMRP mRNA targets and diseases. Cell, 158(6):1446. Pubmed

Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H. (2014) Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. PNAS, 111(36):13205-10. Pubmed

Di Marino D, Achsel T, Lacoux C, Falconi M, Bagni C. (2014) Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function. Journal of Biomolecular Structure and Dynamics, 2014;32(3):337-50. Pubmed


Janusz A, Milek J, Perycz M, Pacini L, Bagni C, Kaczmarek L, Dziembowska M. (2013) The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses. Journal of Neuroscience, 33(46):18234-41.

Fernández E, Rajan N, Bagni C. (2013) The FMRP regulon: from targets to disease convergence. Frontiers in Neuroscience, 7:191. Pubmed

Bagni C, Oostra BA. (2013) Fragile X syndrome: From protein function to therapy. American Journal of Medical Genetics Part A, 161(11):2809-21.

Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, Kuchnio A, Farace MG, Fazio VM, Piacentini M, De Strooper B, Achsel T, Neri G, Neven P, Evans DG, Carmeliet P, Mazzone M, Bagni C. (2013) The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. EMBO Molecular Medicine, 5(10):1523-36.

De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C. (2013) CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation. Neuron, 79(6):1169-82.

Iannilli F, Zalfa F, Gartner A, Bagni C, Dotti CG. (2013) Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B. PLoS One, 8(6):e66602.

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D’Hooge R, Balschun D, Dotti CG. (2013) Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS. Nature Neuroscience,16(4):449-55.

De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Lucà R, Yan J, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J. (2013) Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genetics, 45(2):186-90.


Bagni C, Tassone F, Neri G, Hagerman R. (2012) Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics. Journal of Clinical Investigation, 122(12):4314-22.

Charalambous DC, Pasciuto E, Mercaldo V, Pilo Boyl P, Munck S, Bagni C, Santama N.(2012) KIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner. Cellular and Molecular Life Sciences, 70(2):335-56.

De Rubeis S, Fernández E, Buzzi A, Di Marino D, Bagni C. (2012) Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis. Advances in Experimental Medicine and Biology, 970:517-51

Till SM, Wijetunge LS, Seidel VG, Harlow E, Wright AK, Bagni C, Contractor A, Gillingwater TH, Kind PC.(2012) Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome. Human Molecular Genetics, 15;21(10):2143-56.

Lacoux C, Di Marino D, Boyl PP, Zalfa F, Yan B, Ciotti MT, Falconi M, Urlaub H, Achsel T, Mougin A, Caizergues-Ferrer M, Bagni C. (2012) BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses. Nucleic Acids Research, 40(9):4086-96.

Miroci H, Schob C, Kindler S, Ölschläger-Schütt J, Fehr S, Jungenitz T, Schwarzacher SW, Bagni C, Mohr E. (2012) Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells. Journal of Biological Chemistry, 287(2):1322-34.


De Rubeis S, Bagni C. (2011) Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders. Journal of Neurodevelopmental Disorders, 3(3):257-69.

Tassone F, De Rubeis S, Carosi C, La Fata G, Serpa G, Raske C, Willemsen R, Hagerman PJ,Bagni C. (2011)
Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles. Nucleic Acids Research, 39(14):6172-85.


Maccarrone M, Rossi S, Bari M, De Chiara V, Rapino C, Musella A, Bernardi G, Bagni C, Centonze D.(2010) Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. Neuropsychopharmacology, 35(7):1500-9.
De Rubeis S, Bagni C.(2010) Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability. Molecular and Cellular Neuroscience, 43(1):43-50.


Zukin RS, Richter JD, Bagni C. (2009) Signals, synapses, and synthesis: how new proteins control plasticity. Frontiers in Neural Circuits, 3:14.

Fazi B, Melino S, De Rubeis S, Bagni C, Paci M, Piacentini M, Di Sano F. (2009) Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Oncogene, 28(43):3814-24.

di Penta A, Mercaldo V, Florenzano F, Munck S, Ciotti MT, Zalfa F, Mercanti D, Molinari M, Bagni C, Achsel T. (2009) Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control. Journal of Cell Biology, 184(3):423-35.
Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C. (2008) The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell, 134(6):1042-54.

Tabolacci E, Moscato U, Zalfa F, Bagni C, Chiurazzi P, Neri G. (2008) Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations. European Journal of Human Genetics, 16(12):1487-98.

Florenzano F1, Carrive P, Viscomi MT, Ferrari F, Latini L, Conversi D, Cabib S, Bagni C, Molinari M.(2008) Cortical and subcortical distribution of ionotropic purinergic receptor subunit type 1 (P2X(1)R) immunoreactive neurons in the rat forebrain. Neuroscience, 151(3):791-801.

Centonze D, Rossi S, Mercaldo V, Napoli I, Ciotti MT, De Chiara V, Musella A, Prosperetti C, Calabresi P, Bernardi G, Bagni C. (2008) Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome. Biological Psychiatry, 63(10):963-73.


Centonze D, Rossi S, Napoli I, Mercaldo V, Lacoux C, Ferrari F, Ciotti MT, De Chiara V, Prosperetti C, Maccarrone M, Fezza F, Calabresi P, Bernardi G, Bagni C.(2007) The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum. Journal of Neuroscience, 27(33):8885-92.

Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C. (2007) A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nature Neuroscience, 10(5):578-87.

Tassone F, Beilina A, Carosi C, Albertosi S, Bagni C, Li L, Glover K, Bentley D, Hagerman PJ. Elevated FMR1 mRNA in premutation carriers is due to increased transcription. RNA, 13(4):555-62.

Ferrari F, Mercaldo V, Piccoli G, Sala C, Cannata S, Achsel T, Bagni C. (2007) The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines. Molecular and Cell Neuroscience, 34(3):343-54.

Florenzano F, Viscomi MT, Mercaldo V, Longone P, Bernardi G, Bagni C, Molinari M, Carrive P. (2007) P2X2R purinergic receptor subunit mRNA and protein are expressed by all hypothalamic hypocretin/orexin neurons. Journal of Comparative Neurology, 498(1):58-67.


Zalfa F, Achsel T, Bagni C.(2006) mRNPs, polysomes or granules: FMRP in neuronal protein synthesis. Current Opinion in Neurobiology, 16(3):265-9.

Paronetto MP, Zalfa F, Botti F, Geremia R, Bagni C, Sette C.(2006) The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes. Molecular Biology of the Cell, 17(1):14-24.


Restivo L, Ferrari F, Passino E, Sgobio C, Bock J, Oostra BA, Bagni C, Ammassari-Teule M.(2005) Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. PNAS, 102(32):11557-62.

Baldini PM, De Vito P, D’aquilio F, Vismara D, Zalfa F, Bagni C, Fiaccavento R, Di Nardo P.(2005) Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth. Molecular and Cellular Biochemistry, 272(1-2):19-28.

Zalfa F, Adinolfi S, Napoli I, Kühn-Hölsken E, Urlaub H, Achsel T, Pastore A, Bagni C.(2005) Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif. Journal of Biological Chemistry, 280(39):33403-10.

Bagni C, Greenough WT.(2005) From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nature Reviews Neuroscience, 6(5):376-87.

Zalfa F, Bagni C.(2005) Another view of the role of FMRP in translational regulation. Cellular and Molecular Life Sciences, 62(2):251-2.

Baldini PM, De Vito P, Vismara D, Bagni C, Zalfa F, Minieri M, Di Nardo P.(2005) Atrial natriuretic peptide effects on intracellular pH changes and ROS production in HEPG2 cells: role of p38 MAPK and phospholipase D. Cellular Physiology and Biochemistry, 15(1-4):77-88.

Pietrobono R, Tabolacci E, Zalfa F, Zito I, Terracciano A, Moscato U, Bagni C, Oostra B, Chiurazzi P, Neri G.(2005) Molecular dissection of the events leading to inactivation of the FMR1 gene. Human Molecular Genetics, 14(2):267-77.


Baldini PM, De Vito P, Antenucci D, Vismara D, D’Aquilio F, Luly P, Zalfa F, Bagni C, Di Nardo P.(2004) Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase. Cell Death & Differentiation,11 Suppl 2:S210-2.

Veneri M, Zalfa F, Bagni C.(2004) FMRP and its target RNAs: fishing for the specificity. Neuroreport,15(16):2447-50.

Zalfa F, Bagni C.(2004) Molecular insights into mental retardation: multiple functions for the Fragile X mental retardation protein? Current Issues in Molecular Biology, 6(2):73-88.


Zalfa F, Giorgi M, Primerano B, Moro A, Di Penta A, Reis S, Oostra B, Bagni C.(2003) The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell, 112(3):317-27.


Primerano B, Tassone F, Hagerman RJ, Hagerman P, Amaldi F, Bagni C.(2002) Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations. RNA, 8(12):1482-8.

Bagni C, Bray S, Gogos JA, Kafatos FC, Hsu T.(2002) The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Mechanisms of Development, 117(1-2):265-8.


Signori E, Bagni C, Papa S, Primerano B, Rinaldi M, Amaldi F, Fazio VM.(2001) A somatic mutation in the 5’UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency. Oncogene, 20(33):4596-600.

Pepe G, Giusti B, Evangelisti L, Porciani MC, Brunelli T, Giurlani L, Attanasio M, Fattori R, Bagni C, Comeglio P, Abbate R, Gensini GF.(2001) Fibrillin-1 (FBN1) gene frameshift mutations in Marfan patients: genotype-phenotype correlation. Clinical Genetics, 59(6):444-50.

Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL.(2001) A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. PNAS, 98(15):8844-9.

Cannata SM, Bagni C, Bernardini S, Christen B, Filoni S.(2001) Nerve-independence of limb regeneration in larval Xenopus laevis is correlated to the level of fgf-2 mRNA expression in limb tissues. Developmental Biology, 231(2):436-46.


Bagni C, Mannucci L, Dotti CG, Amaldi F.(2000) Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes. Journal of Neuroscience, 20(10):RC76.


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